However, now we have to define sepsis as a life-threatening organ dysfunction caused by infection.

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Andréia Patrícia Gomes Departamento de Medicina e Enfermagem Universidade Federal de Viçosa, Avenida P. Rolfs, s/n Campus Universitário, CEP: 36571-000 - Viçosa (MG), Brasil Tel: (31) 3899-3978 E-mail: [email protected] Received date: June 10, 2016; Accepted date: July 28, 2016; Published date: August 12, 2016 Citation: Gomes AP, Alves DLS, Miguel PSB, Inoue VH, Correia Lopes TC et al.

The purpose of this paper is to review the role of the anti-inflammatory cytokines in sepsis and present perspectives on the in silico investigation of the role of these mediators in this nosological entity, using the computational system Auto Simmune.

Cytokines, Inflammation, In silico research, Sepsis. Cytokines are low molecular weight proteins (polypeptides) or glycoproteins secreted by leukocytes and by various other cells in the organism, in response to diverse stimuli [1].

There are cytokines that function primarily as inductors of inflammation - pro-inflammatory cytokines -, while others act in counter regulation processes - the antiinflammatory cytokines [4].

The inflammatory response is controlled by both groups of cytokines.Visit for more related articles at Journal of Pharmaceutical Care & Health Systems The pathophysiology, diagnosis, treatment and prognosis of sepsis remain major challenges for contemporary clinical practice.In this sense, efforts to broaden the knowledge about the mechanisms involved in systemic inflammation and to identify new methods for detecting sepsis in the early stages and the stratification of patients are extremely important.The rate of occurrence is high, with over 1665 cases of sepsis occurring yearly in the United States, reaching a lethality rate of 20–50 percent [8].It is also important to note that, even with ideal treatment, the possibility of death is approximately 40 percent and can be greater than 50 percent in the most severe cases [9-12].Thus, 1,651 citations were obtained, from which 21 papers were selected.